Erectile dysfunction(ED) is the inability to maintain penile erection for the successful performance of sexual activity.Sexual stimulation causes the smooth muscle cells of the arteries in the penis to relax. As a result ,more blood flows into the sinusoids,and their volume increases. The penis becomes swollen and erect.
Main drugs used for erectile dysfunction are Sildenafil (Brand name: Viagra), Tadalafil (Brand name:cialis) and Vardenafil(Brand name:Levitra). All are orally active drugs for the treatment of ED.
This medicine should be taken approximately 1hour prior to anticipated sexual activity,with erectile enhancement upto 4 hours after administration.Its use is now standard treatment for erectile dysfunction in all settings, including Diabetes. As well as erectile dysfunction, sildenafil citrate is also effective in the rare disease Pulmonary arterial hypertension. It relaxes the arterial wall, leading to decreased pulmonary arterial resistance and pressure. This, in turn, reduces the workload of the right ventricle of the heart and improves symptoms of right-sided heart failure. Absorption of sildenafil is delayed by consumption of food ,particularly high fat meals.
Most frequent adverse effects
Headache,flushing,dyspepsia , nasal congestion and disturbances in colour vision. Sildenafil is contraindicated in patients with history of stroke or heart attack. Also contraindicated in patients with hypotension,hepatic impairment and patients with severe impairment in renal function.
This medicine is used for Erectile dysfunction , Pulmonary arterial hypertension and treating the signs and symptoms of Benign prostatic hyperplasia.Cialis(tadalafil) is the only one of the three that is also offered as a once-daily medication.Tadalafil has a slower oncet of action but a significantly longer half life of approximately 18 hours,resulting in enhanced crectile function for at least 36hours.Tadalafil is not influenced by food or alcohol intake.
The most common side effects
when using tadalafil headache, stomach discomfort or pain will be there other side effects are indigestion, burping, acid reflux. back pain, muscle aches, flushing, and stuffy or runny nose. Back pain and muscle aches can occur 12 to 24 hours after taking the drug, and the symptom usually disappears after 48 hours.
This medicine is also used for treating erectile dysfunction. Beyond its indications for erectile dysfunction, vardenafil may be effective in the treatment of premature ejaculation, where it may significantly increase the time from penetration to ejaculation.Vardenafil should be taken approximately 1hour prior to anticipated sexual activity,with erectile enhancement upto 4 hours after administration. Absorption of sildenafil is delayed by consumption of food, paricularly high fat meals.
Most frequent adverse effects
headache, flushing, dyspepsia , nasal congestion, hypotension, tachycardia, myalgia and abnormal vision.