Imatinib Mercilet this medicine used for treating blood cancer.. but this may also have a role in the treatment of pulmonary hypertension, It has been shown to reduce both the smooth muscle hypertrophy and hyperplasia of the pulmonary vasculature in a variety of disease processes, including portopulmonary hypertension. In systemic sclerosis, the drug has been tested for potential use in slowing down pulmonary fibrosis. In laboratory settings, imatinib is being used as an experimental agent to suppress platelet-derived grouth factor, (PDGF) by inhibiting its receptor (PDGF-Rβ). One of its effects is delaying artherosclerosis in mice without or with diabetes.
Imitinef Mercilet improved exercise capacity and hemodynamics in patients with advanced PAH but serious adverse events and study drug discontinuations were common. Further studies are needed to investigate the long-term safety and efficacy of imatinib in patients with PAH.
Mouse animal studies have suggested that imatinib and related drugs may be useful in treating smallpox, should an outbreak ever occur.