(MDECG) A Study of the Human Heart as a Multiple Dipole Electrical Source, Diagnosis and Quantitation of Right Ventricular Hypertrophy

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The multiple dipole electrocardiographic (MDECG) method proposed earlier was evaluated further by testing its ability to diagnose and quantitate right ventricular hypertrophy (RVH). Two series of subjects were used. The first series consisted of patients with conditions giving a pressure overload of the right ventricle (RV), the RV systolic pressure (RVSP) being used to indicate the severity of RVH. The second series consisted of patients for whom a surgeon’s visual estimate of RV size was available. A series of normal subjects was also used. For the first series a sensitivity of 85% for RVH diagnosis by MDECG was obtained, the specificity based on the normal series being 94%. The second, more inhomogeneous, series yielded a sensitivty of 75% and a specificity of 75%. This diagnostic performance was better than that obtained with conventional electrocardiographic or vectorcardiographic methods applied to the same patients.

To assess the quantitative ability of the MDECG, the results obtained for the first series were correlated with RVSP. A coefficient of determination for r2 of 86% (standard error of RVSP estimate being 11 mm Hg) was obtained.

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