New Drug that can protect against radiation
New Drug That Can Protect Against
Radiotherapy or radiation can damage healthy cells, Now scientist from US introduced a drug which may protect the body against damage from radiation. Now there is a big hope that radiotherapy safer for people with cancer. And this drugs can use in nuclear disaster.
The name of the drug is CBLB502, and is drug developed by Cleveland Bio Labs, Inc, in Buffalo, New York.
Radiation damages healthy cells in a way that causes them to activate the regulated cell death process, known as apoptosis. CBLB502 temporarily suppresses this response, enabling healthy cells to increase radiation resistance, and also reduces oxidative damage and induces regeneration-promoting cytokines.
If the protective properties seen in this laboratory study can be reproduced in people with cancer, this could be an important step towards reducing side effects for people having radiotherapy.
Dr Joanna Owens, Cancer Research UK Researchers developed the drug after looking at how some resistant cancer cells are able to withstand radiotherapy.It works by inhibiting the protein that initiates the cell suicide programme. Studies in animals suggest CBLB502 protects healthy cells in the bone marrow and digestive tract against radiation but does not seem to protect tumour cells which remain vulnerable to treatment.
This drug tested in animals. Mice and monkeys injected with the drug between 45 minutes and 24 hours before being subjected to normally lethal radiation were more likely to survive or live longer than untreated animals, the researchers found.
Side effects CBLB502
One risk of preventing cell death is that defective cells may be allowed to survive which could then turn cancerous. However, the researchers found no sign of this happening in the laboratory tests on mice.
Also, there were no apparent side effects. Protecting healthy cells against the effects of radiation may allow cancer patients to receive higher doses of radiotherapy, or longer courses of treatment.
The drug may also be useful in protecting against fall out from a nuclear disaster, such as Chernobyl, or the effects of a terrorist “dirty bomb”.
Dr Andrei Gudkov from the Lerner Research Institute in Cleveland, Ohio, said they had set out to enable healthy cells to imitate the ability of tumour cells to avoid cell death. But they had to develop a way of making this effect temporary and reversible.
CBLB502 reduces radiation toxicity without diminishing the therapeutic anti-tumour effect of radiation and without promoting radiation-induced carcinogenicity. If the protective properties seen in this laboratory study can be reproduced in people with cancer, this could be an important step towards reducing side effects for people having radiotherapy.”